郭彩霞----中国科学院北京基因组研究所

负责人简介
研究方向
发表论著
承担科研项目
项目组简介
项目组最新成果

郭彩霞(GUO Caixia)

研究员博士生导师

E-Mail：guocx@big.ac.cn

研究领域：生物化学与分子生物学

项目组负责人简介：

学习经历：
1987年9月-1991年8月武汉大学生物系学士学位
1991年9月-1994年8月武汉大学生命科学院理学硕士学位
1994年9月-1999年8月中国科学院动物研究所生理学博士学位

工作经历：

1999年10月至2001年1月美国肯塔基大学生理系博士后
2001年1月至2004年美国德克萨斯州西南医学中心病理系博士后
2004年至2008年美国德克萨斯州西南医学中心病理系Instructor
2008年3月至2009年8月美国德克萨斯州西南医学中心病理系助理教授
2009年至今中国科学院北京基因组研究所研究员

学术兼职：
Genomics, Proteomics & Bioinformatics 编委(2010-)

获奖及荣誉：

2016年中国科学院“朱李月华优秀教师”奖

近期主要学术成果：

近五年发表文章（*代表通讯作者）

1. Huang M, Zhou B, Gong J, Xing L, Ma X, Wang F, Wu W, Shen H, Sun C, Zhu X, Yang Y, Sun Y, Liu Y, Tang TS*, Guo C*. RNA-splicing factor SART3 regulates translesion DNA synthesis. Nucleic Acids Res. (2018). Online.

2. Xie C, Shen H, Zhang H, Yan J, Liu Y, Yao F, Wang X, Cheng Z*, Tang TS*, Guo C*. Quantitative proteomics analysis reveals alterations of lysine acetylation in mouse testis in response to heat shock and X-ray exposure. Biochim Biophys Acta. (2018). 1866(3): 464-472.

3. Sun Z, Zhang H, Wang X, Wang Q, Zhang C, Wang J ,Wang Y, An C, Yang K, Wang Y, Gao F, Guo C*, Tang TS*. TMCO1 is essential for ovarian follicle development by regulating ER Ca2+ store of granulosa cells. Cell Death Differ. (2018). doi:10.1038/s41418-018-0067-x

4. Zhu, X, Ma X, Tu Y, Huang M, Liu H, Wang F, Gong J, Wang J, Li X, Chen Q, Shen H, Zhu S, Wang Y, Liu Y, Guo C*, Tang TS*. Parkin regulates translesion DNA synthesis in response to UV radiation. Oncotarget. (2017). 8, 36423-36437.

5. Gong J, Huang M, Wang F, Ma X, Liu H, Tu Y, Xing L, Zhu X, Zheng H, Fang J, Li X, Wang Q, Wang J, Sun Z, Wang X, Wang Y, Guo C*, Tang TS*. RBM45 competes with HDAC1 for binding to FUS in response to DNA damage. Nucleic Acids Res. (2017).45, 12862–12876.

6. Ma X, Liu H, Li J, Wang Y, Ding YH, Shen H, Yang Y, Sun C, Huang M, Tu Y, Liu Y, Zhao Y, Dong MQ, Xu P, Tang TS*, Guo C*. Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis. Nat Commun. (2017). 8, 1941.

7. Tu, Y, Liu H, Zhu X, Shen H, Ma X, Wang F, Huang M, Gong J, Li X, Wang Y, Guo C*, Tang TS*. Ataxin-3 promotes genome integrity by stabilizing Chk1. Nucleic Acids Res. (2017).45, 4532-4549.

8. Sun X, Cai X, Yang J, Chen J, Guo C*, Cao P*. Overcomes Imatinib Resistance by Depleting BCR-ABL in Chronic Myeloid Leukemia. Mol Cells. (2016). 39(12):869-876.

9. Liu H, Li X, Ning G, Zhu S, Ma X, Liu X, Liu C, Huang M, Schmitt I, Wüllner U, Niu Y, Guo C*, Wang Q*, Tang TS*. The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53. PLOS Biol. (2016). 14(11):e2000733.

10. Wang K, Ma X, Zhang X, Wu D, Sun C, Sun Y, Lu X, Wu CI, Guo C*, Ruan J*. Using ultra-sensitive next generation sequencing to dissect DNA damage-induced mutagenesis. Sci Rep. (2016). 6:25310.

11. Sun Y, Yang Y, Shen H, Huang M, Wang Z, Liu Y, Zhang H, Tang TS, Guo C*. iTRAQ-based chromatin proteomic screen reveals CHD4-dependent recruitment of MBD2 to sites of DNA damage. Biochem Biophys Res Commun. (2016). 471(1):142-8.

12. Wang Z, Huang M, Ma X, Li H, Tang T, Guo C*. REV1 promotes PCNA monoubiquitination through interacting with ubiquitinated RAD18. J Cell Sci. (2016). 129:1223-1233.

13. Yan J, Zhang H, Liu Y, Zhao F, Zhu S, Xie C, Tang TS, Guo C*. Germline Deletion of Huntingtin Causes Male Infertility and Arrested Spermiogenesis in Mice. J Cell Sci. (2016). 129: 492-501.

14. Liu Y, Ma X, Guo C*. Effects of the N terminus of mouse DNA polymerase κ on the bypass of a guanine-benzo[a]pyrenyl adduct. J Biochem. (2015).pii: mvv118.

15. Yang Y, Liu Z, Wang F, Temviriyanukul P, Ma X, Tu Y, Lv L, Lin Y, Huang M, Zhang T, Pei H, Chen B, Jansen JG, Wind N, Fischhaber P, Friedberg EC, Tang TS and Guo C*. FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress. Nucleic Acids Res. (2015).43, 8325-8339

16. Dong S, Han J, Chen H, Liu T, Huen MS, Yang Y, Guo C, Huang J. The Human SRCAP Chromatin Remodeling Complex Promotes DNA-End Resection. Curr Biol. (2014).24(18):2097-110.

17. Wang F, Fischhaber PL, Guo C, Tang TS. Epigenetic modifications as novel therapeutic targets for Huntington's disease. Epigenomics. (2014).6(3):287-97.

18. Gao M, Wei W, Li MM, Wu YS, Ba Z, Jin KX, Li MM, Liao YQ, Adhikari S, Chong Z, Zhang T, Guo C, Tang TS, Zhu BT, Xu XZ, Mailand N, Yang YG, Qi Y, Rendtlew Danielsen JM. Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination. Cell Res. (2014). 24(5):532-41.

19. Liu Y, Yang Y, Tang TS, Zhang H, Wang Z, Friedberg EC, Yang W, Guo C*. Variants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[a]pyrene dG adduct. Proc Natl Acad Sci USA. (2014).111(5): 1789-1794.

20. Lv L, Wang F, Ma X, Yang Y, Wang Z, Liu H, Li X, Liu Z, Zhang T, Huang M, Friedberg E, Tang TS, Guo C*. Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation. Nucleic Acid Res. (2013).41(22):10312-10322.

21. Wang F, Yang Y, Lin X, Wang JQ, Wu YS, Xie W, Wang D, Zhu S, Liao YQ, Sun Q, Yang YG, Luo HR, Guo C*, Han C*, Tang TS*. Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease. Human Mol Genet. (2013).22(18):3641-3653.

22. Zhang X, Lv L, Chen Q, Yuan F, Zhang T, Yang Y, Zhang H, Wang Y, Jia Y, Qian L, Chen B, Zhang Y, Friedberg C, Tang T and Guo C*. Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks. DNA Repair. (2013).12(5):377-88.