吴仲义----中国科学院北京基因组研究所

简介
研究方向
发表论著
承担科研项目
项目组情况
招生信息

吴仲义(WU Chung-I)

博士生导师，研究员，台湾中研院院士

E-Mail：wuci(AT)big.ac.cn

研究领域：遗传学基因组学生物信息学

导师简介：

学习经历：
1972年-1976年台湾东海大学生物学学士
1977年-1982年加拿大英属哥伦比亚大学遗传学博士

工作经历：

2008年6月至今中国科学院北京基因组研究所研究员

2008年6月-2014年5月中国科学院北京基因组研究所所长

2004年7月-2008年5月中山大学长江学者

1998年7月-2008年5月芝加哥大学教授

1998年7月-2006年6月芝加哥大学生态与进化系系主任

1991年7月-1998年6月芝加哥大学副教授

1990年9月-1991年6月罗彻斯特大学副教授

1986年8月-1990年8月罗彻斯特大学助理教授

1985年1月-1986年7月威斯康辛大学麦迪逊分校博士后

1982年6月-1984年12月德克萨斯大学休斯顿健康中心助理研究员

1976年9月-1977年8月台湾东海大学助教

学术兼职：
NCBI: Member of Adviser Board
NCBI: Scientific Cousellor
加利福尼亚大学旧金山分校Center of Evolution and Cancer: Ajunct Professor
芝加哥大学 Institute of Genomics and system biology: Senior Fellow

获奖及荣誉：

1990-1995年获得NIH研究职业发展奖

1989-1991获得全国唐氏综合症协会奖

2004年获得台湾东海大学优秀毕业生奖

2004年被评为中研院院士

2011年国家自然科学奖二等奖

2013年度、2014年度中国科学院“优秀研究生指导教师”奖

近期主要学术成果：

（# co-first author， * Corresponding author）

1.Guojing Liu#, Rui Zhang#, Jin Xu, Chung-I Wu* and Xuemei Lu*. Functional conservation of both CDS- and 3’UTR- located miRNA binding sites between species. Molecular biology and evolution, 2015, 32(3): 623-628

2.Yang Lyu, Yang Shen, Heng Li, Yuxin Chen, Li Guo, Yixin Zhao, Eric Hungate, Suhua Shi, Chung-I Wu*, and Tian Tang*. New microRNAs in Drosophila--birth, death and cycles of adaptive evolution. PLoS genetics. 2014; 10, e1004096.

3.Jin Xu#，Rui Zhang#，Yang Shen，Guojing Liu，Xuemei Lu，Chung-I Wu*. The evolution of evolvability in microrna target sites in vertebrates. Genome research. 2013;23:1810-1816

4.Zechen Chong#，Weiwei Zhai#，Chunyan Li，Min Gao，Qiang Gong，Jue Ruan，Juan Li，Lan Jiang，Xuemei Lu，EricHungate，Chung-I Wu*. The evolution of small insertions and deletions in the coding genes of drosophila melanogaster. Molecular biology and evolution. 2013;30:2699-2708

5.Zheng Hu, Yunxin Fu, Anthony J Greenberg, Chung-I Wu*, Weiwei Zhai*. Age-dependent transition from cell-level to population-level control in murine intestinal homeostasis revealed by coalescence analysis. PLoS genetics. 2013; 9, e1003326.

6.Guodong Wang#, Weiwei Zhai#, HechuangYang, Ruoxi Fan, Xue Cao, Li Zhong, Lu Wang, Fei Liu, Hong Wu, Luguang Cheng, Andrei D. Poyarkov, Nikolai A. Poyarkov JR, Shu-sheng Tang, Wenming Zhao, Yun Gao, Xuemei Lu, David M. Irwin, Peter Savolainen, Chung-I Wu*, Yaping Zhang*. The genomics of selection in dogs and the parallel evolution between dogs and humans. Nature communications. 2013;4:1860-1864

7.Jue Ruan#, Lan Jiang#, Zechen Chong#, Qiang Gong#, Heng Li, Chunyan Li, Yong Tao, Caihong Zheng, Weiwei Zhai, David Turissini, Charles H Cannon, Xuemei Lu*, Chung-I Wu*. Pseudo-sanger sequencing: Massively parallel production of long and near error-free reads using NGS technology. BMC genomics. 2013; 14(1): 711-719

8.Qiang Gong, Yong Tao, Jianrong Yang, Jun Cai, Yunfei Yuan, Jue Ruan, Jin Yang, Huiliang Liu, Wanghua Li, Xuemei Lu, Shimei Zhuang, Sanming Wang, Chung-I Wu*. Identification of medium-sized genomic deletions with low coverage, mate-paired restricted tags. BMC genomics. 2013;14:51-55

9.Caihong Zheng, Xuexia Miao, Yanen Li, Ying Huang, Jue Ruan, Xi Ma, Li Wang, Chung-I Wu*, and Jun Cai*. Determination of genomic copy number alteration emphasizing a restriction site-based strategy of genome re-sequencing. Bioinformatics. 2013; 29, 2813-2821.

10.Shu Fang, Roman Yukilevich, Ying Chen, David A Turissini, Kai Zeng, Ian A Boussy, and Chung-I Wu*. Incompatibility and competitive exclusion of genomic segments between sibling Drosophila species. PLoS genetics. 2012;8, e1002795.

11.Zecheng Chong#, Jue Ruan# *, and Chung-I Wu*. Rainbow: an integrated tool for efficient clustering and assembling RAD-seq reads. Bioinformatics. 2012; 28, 2732-2737.

12.Ziwen He, Xinnian Li, Shaoping Ling, Yunxin Fu, Eric Hungate, Suhua Shi*, Chung-I Wu*. Estimating DNA polymorphism from next generation sequencing data with high error rate by dual sequencing applications. BMC genomics. 2013; 14, 535.

13.Yong Tao#, Jue Ruan#, Shiou-Hwei Yeh#, Xuemei Lu#, Yu Wang#, Weiwei Zhai#, Jun Cai#, Shaoping Ling, Qiang Gong, Zechen Chong, Zhengzhong Qu, Qianqian Li, Jiang Liu, Jin Yang, Caihong Zheng, Changqing Zeng, Hurng-Yi Wang, Jing Zhang, Sheng-Han Wang, Lingtong Hao, Lili Dong, Wenjie Li, Min Sun, Wei Zou, Caixia Yu, Chaohua Li, Guojing Liu, Lan Jiang, Jin Xu, Huanwei Huang, Chunyan Li, Shuangli Mi, Bing Zhang, Baoxian Chen, Wenming Zhao, Songnian Hu, Shi-Mei Zhuang, Yang Shen, Suhua Shi, Christopher Brown, Kevin P.White, Ding-Shinn Chen*, Pei-Jer Chen, Chung-I Wu*. Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. Proc Natl Acad Sci USA. 2011;108:12042-12047

14.Renchao Zhou#, Shaoping Ling#, Wenming Zhao#, Naoki Osada, Sufang Chen, Meng Zhang, Ziwen He, Hua Bao, Cairong Zhong, Bing Zhang, Xuemei Lu, David Turissini, Norman C. Duke, Jian Lu*, Suhua Shi*, Chung-I Wu*. Population genetics in nonmodel organisms: Ii. Natural selection in marginal habitats revealed by deep sequencing on dual platforms. Molecular biology and evolution. 2011; 28(10): 2833-2842

15.Yang Shen, Yang Lv, Lei Huang, Wensheng Liu, Ming Wen, Tian Tang, Rui Zhang, Eric Hungate, Suhua Shi*, Chung-I Wu*. Testing hypotheses on the rate of molecular evolution in relation to gene expression using microRNAs. Proc Natl Acad Sci USA. 2011;108, 15942-15947.

16.Ziwen He#, Weiwei Zhai#, Haijun Wen#, Tian Tang, Yu Wang, Xuemei Lu, Anthony J. Greenberg, Richard R. Hudson, Chung-I Wu*, Suhua Shi*. Two evolutionary histories in the genome of rice: The roles of domestication genes. PLoS genetics. 2011; 7(6): 1-3

17.Xuemei Lu, Chung-I Wu*. Sex, sex chromosomes and gene expression. BMC biology. 2011;9:30-32

18.Xuemei Lu#, Joshua A. Shapiro#, Chau-Ti Ting, Yan Li, Chunyan Li, Jin Xu, Huanwei Huang, Ya-Jen Cheng, Anthony J. Greenberg, Shou-Hsien Li, Mao-Lien Wu, Yang Shen, Chung-I Wu*. Genome-wide misexpression of x-linked versus autosomal genes associated with hybrid male sterility. Genome research. 2010; 20(8): 1097-1102

19.Tian Tang#, Supriya Kumar#, Yang Shen, Jian Lu, Maolien Wu, Suhua Shi, Wen-Hsiung Li*, Chung-I Wu*. Adverse interactions between micro-RNAs and target genes from different species. Proc Natl Acad Sci USA. 2010;107, 12935-12940.

20.Guodong Wang#, Ruoxi Fan#,Weiwei Zhai, Fei Liu, Lu Wang, Li Zhong, Hong Wu, Hechuan Yang, Shifang Wu,Chunling Zhu, ,Yan Li, Yun Gao, Rili Ge, Chung-I Wu, Yaping Zhang*. Genetic convergence in the adaptation of dogs and humans to the high-altitude environment of the tibetan plateau. Genome biology and evolution. 2014; 6, 2122-2128.

21.Shanye Yin#, Jing Yang#, Bin Lin#, Wenjun Deng#, Yuchao Zhang, Xianfu Yi,Yufang Shi, Yong Tao, Jun Cai, Chung-I Wu, Guoping Zhao, Laurence D Hurst, Jie Zhang, Landian Hu*, Xiangyin Kong*. Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients. Scientific reports. 2014; 4, 6036.

22.Lan Jiang#, Jing Zhang#, Jing-Jing Wang#, Lu Wang, Li Zhang, Guoqiang Li, Xiaodan Yang,Xin Ma, Xin Sun, Jun Cai, Jun Zhang, Xingxu Huang, Miao Yu, Xuegeng Wang, Feng Liu, Chung-I Wu, Chuan He, Bo Zhang, Weimin Ci*, Jiang Liu*. Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos, Cell, 2013, 153, 773-84, (Cover story，highlighted by Cell, Nature Review Genetics, etc.）

专利：

1.李春燕，杨芳，刘稳升，王瑜，吕雪梅，吴仲义，用于恶性肿瘤治疗的组合物及其应用，中国，201210046682.0 专利

2.李春燕，董恩成，刘珍珍，吕雪梅，吴仲义，筛选肿瘤早期诊断靶标的Small RNA-Seq库的构建方法，中国，201210041472.2 专利