Faculty and Staff

WANG Qianfei
E-mail:wangqf@big.ac.cn

Group leader

Dr. WANG Qianfei "Jeffrey" is currently a professor and principal investigator at Beijing Institute of Genomics (BIG), Chinese Academy of Sciences (CAS). He is also a joint professor at the State Key Laboratory of Experimental Hematology and a member of the 13th and 14th expert committee in Medical Sciences of National Natural Science Foundation of China. He was awarded the National Science Fund for Distinguished Young Scholars in 2014.

Dr. WANG received his bachelor degree in clinical medicine from Shandong Medical University in China. He then earned his Ph.D. from Johns Hopkins University School of Medicine in 2002 (thesis advisors: Drs. Mark Schlissel and Alan Friedman). Under the supervision of Dr. Edward Rubin, Dr. WANG pursued his postdoctoral training in the Genomics Division at Lawrence Berkeley National Laboratory, University of California, Berkeley. Before Dr. WANG joined the faculty at Beijing Institute of Genomics, he was an Assistant Professor (Research Associate) at Section of Hematology/Oncology, the University of Chicago (2007-2009). Dr. WANG's background in clinical medicine, experimental biology and genomics has provided him with a unique opportunity to decipher the molecular mechanism and regulatory network controlling hematopoiesis and the development of human leukemia.

 

Introduction   

Leukemia is a malignant disease characterized by the uncontrolled accumulation of blood cells. Leukemia causes more deaths than any other cancer among children and young adults under the age of 20. Despite multi agent chemotherapy and stem cell transplantation, the overall survival rate of acute myeloid leukemia is less than 30%.

Through integrative programs combining biochemistry, cellular/molecular biology, and powerful genomics technology platforms, we seeks to transform original raw genomics data and basic research insights into knowledges of precision medicine related to AML diagnosis and treatment. Our lab has employed a combined genomic and functional characterization strategy to: 1) explore the functional and clinical relevance of newly discovered genomic aberrations in acute leukemia; 2) identify key genes/pathways critical for drug resistance in chemotherapy; 3) define genomic signatures for the classification of responders in AML drug treatment.

  

Selected Publications

1. Loss of Asxl2 leads to myeloid malignancies in mice.

Nature Communications (Accepted).

Li JP, He FH, Zhang P, Chen S, Shi H, Sun YL, Guo Y, Yang H, Man N, Greenblatt S, Li ZM, Guo ZY, Zhou Y, Wang L, Morey L, Williams S, Chen X, Wang QT, Nimer S, Yu P, Wang QF*, Xu MJ* and Yang FC*.

2. Expression profiling-based clustering of healthy subjects recapitulates classifications defined by clinical observation in Chinese medicine.
Journal of Genetics and Genomics. 44(4):191-7,2017
Yu RX, Liu D, Yang Y, Han YY, Li LR, Zheng LY, Winges DM, Wang J, Zhang Y, Wang QF* and Wang Q*.

3. Loss of Asxl1 alters self-renewal and cell fate of bone marrow stromal cell, leading to bohring-opitz-like syndrome in mice.

Stem Cell Reports. 6(6):914-25,2016

Zhang P, Xing CH, Rhodes SD, He YZ, Deng K, Li ZM, He FH, Zhu CY, Nguyen L, Zhou Y, Chen S, Mohammad K S, Guise TA, Abdel-Wahab O, Xu MJ, Wang QF* and Yang FC*.

4. The priming induction regimen of HAG as a low dose chemotherapy strategy in AML clonal evolution.

Sci China Life Sci. 58(12):1302-5,2015

Chen A, Yang J, Hu S* and Wang QF*.

5.Cell Type-Specific Expression Profile and Signaling Requirements in Early Hematopoietic Reprogramming.

Stem Cells Dev. 24(12):1483-92,2015

Kang L*, Wu J, Tao Y, Li HL, Liu XL, Gao SR* and Wang QF*.

6. Evidences for mutations in the histone modifying gene SETD2 as critical drivers in leukemia development.

Sci China Life Sci.57(9):944-6,2014

Wang QF* and Cheng T*.

7. Whole-genome sequencing identifies genetic variances in culture-expanded human mesenchymal stem cells.

Stem Cell Reports.3(2):227-33,2014

Cai J, Miao XX, Li YY, Smith C, Tsang K, Cheng LZ* and Wang QF*.

8. Identification of functional cooperative mutations of SETD2 in human acute leukemia.

Nature Genetics. 46(3):287-93,2014

Zhu XF, He FH, Zeng HM, Ling SP, Chen AL, Wang YQ, Yan XM, Wei W, Pang YK, Cheng H, Hua CL, Zhang Y, Yang XJ, Lu X, Cao LH , Hao LT, Dong LL, Zou W, Wu J, Li X, Zheng S, Yan J, Zhou J, Zhang LX , Mi SL, Wang XJ, Zhang L, Zou Y, Chen YM, Geng Z, Zhou JF, Wang JM, Liu X, Wang JX, Yuan WP, Huang G*, Cheng T* and Wang QF*.

9. PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway.

Leukemia. 28(7):1436-48,2014

Zhou J, Wu J, Li B, Liu D, Yu J, Yan XM, Zheng S, Wang JG, Zhang LX, Zhang L, He FH, Li Q, Chen AL, Zhang Y, Zhao XH, Guan YH, Zhao XH, Yan J, Ni J, Nobrega M, L? wenberg B, Delwel R, Valk P J, Kumar A, Xie L, Tenen DG, Huang G* and Wang QF*.

10. Regulation of MEIS1 by distal enhancer elements in acute leukemia.

Leukemia.28:138-46,2014

Wang QF*, Li YJ, Dong JF, Li B, KaberleinJJ, Zhang L, Arimura FE, Luo RT, Ni J, He FH, Wu J, Mattison R, Zhou J, Wang CZ, Prabhakar S, Nobrega M A and Thirman M J*.

11. H3.3 actively marks enhancers and primes gene transcription via opening higher-ordered chromatin.

Genes Development. 27(19):2109-24,2013

Ping Chen, Jicheng Zhao, Wang Y, Wang M, Long HZ, Liang D, Huang L, Wen ZQ, Li W, Li X, Feng HL, Zhao HY, Zhu P, Li M, Wang QF and Li GH.

12. Differential principal component analysis of CHIP-seq.

PNAS. 110(17):6789-94,2013

Ji HK, Li X, Wang QF and Ning Y.

13. iASeq: integrative analysis of allele-specificity of protein-DNA interactions in multiple ChIP-seq datasets.

BMC Genomics. 13:681, 2012

Wei YY#, Li X#, Wang QF and Ji HK. (co-first author)

14. MLL fusion proteins preferentially regulate a subset of wild type MLL target genes in the leukemic genome.

Blood. 117(25):6895-905,2011

Wang QF, Wu G, Mi SL, He FH, Wu J, Dong JF, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji HK and Thirman MJ.

15. Methylation and expression analysis of tumor suppressor genes p15 and p16 in benzene poisoning.

Chemico-Biological Interactions. 184:306-9,2010

Xing C*, Wang QF*, Li B, Tian H, Ni Y, Yin S and Li G.

16. Detection of weakly conserved ancestral mammalian regulatory sequences by primate comparisons.

Genome Biology. 8(1):R1, 2007

Wang QF*, Prabhakar S, Chanan S, Cheng JF, Rubin EM and Boffelli D*.

17. Primate-specific evolution of an LDLR enhancer.

Genome Biology. 7(8):R68, 2006

Wang QF#, Prabhakar S#, Wang Q, Moses A, Chanan S, Brown M, Eisen M, Cheng JF, Rubin E and Boffelli D.

18. Haplotypes in the APOA1-C3-A4-A5 Gene Cluster affect Plasma Lipids in both Humans and Baboons.

Human Molecular Genetics.13(10): 1049-56, 2004

Wang QF, Liu X, O’nell J, Peng Z, Krauss R, Rainwater DL, Vandeberg JL, Rubin EM, Cheng J F and Pennacchio LA.

19. Cell cycle inhibition mediated by the outer surface of the C/EBPalpha basic region is required but not sufficient for granulopoiesis.

Oncogene. 22(17):2548-57, 2003

Wang QF, Cleaves R, Kummalue T, Nerlov C and Friedman A D.

20. C/EBPs are required for granulopoiesis independent of their induction of the granulocyte-colony stimulating factor receptor.

Blood. 99(8): 2776- 85, 2002

Wang QF and Friedman A D.

21. c-Myb binds to a sequence in the proximal region of the RAG-2 promoter and is essential for promoter activity in T-lineage cells.

Molecular and Cellular Biology.20:9203-11, 2000

Wang QF, Lauring J, and Schlissel M S.

 

Patents

Cheng Tao, Wang Qianfei, Zhu Xiaofan, Yuan Weiping, Assay kit for detecting mutations in the SETD2 gene (SETD2), 2015.3.11, China, ZL 201310107889.9

 

Awards and Honors

2014 The National Science Fund for Distinguished Young Scholars

2015 Zhu Liyuehua Excellent Teacher Award

2015 National Hundred, Thousand and Ten Thousand Talents Project

2016 State Council Expert for Special Allowance

 

Group Members

Staff:

YAN Jin: Research assistant

LI Yueying: Research assistant professor (Experimental biology)

CHEN Aili: Research assistant professor (Experimental biology)

Graduate Students:

2011

YANG Xuejing (Experimental biology)

2012

ZHAN Di (Experimental biology)

BU Jiachen (Experimental biology)

2013

JIN Chen(Experimental biology)

2014

XU Zehui (Bioinformatics)

DOAA KHALED A ALAMOUDI (Experimental biology)

2015

YANG Jingyi (Experimental biology)

SUN Shu (Experimental biology)

2016

ZHANG Ya (Experimental biology)

CHEN Lei (Experimental biology)

Visiting Graduate Students:

2015

WU Bo (Experimental biology)

2016

LIAN Nan (Experimental biology)

 

Lab News Links:

http://dwz.cn/3ui4pR

http://scitech.people.com.cn/n/2015/0605/c1007-27107129.html

http://news.xinhuanet.com/tech/2015-02/04/c_1114251835.htm

http://news.cntv.cn/2014/02/13/VIDE1392248522320199.shtml

http://paper.people.com.cn/rmrbhwb/html/2014-02/11/content_1389066.htm

http://www.big.cas.cn/xwzx/zhxw/201601/t20160129_4527272.html

http://www.big.ac.cn/xwzx/kyjz/201412/t20141205_4269647.html

http://www.big.cas.cn/xwzx/zhxw/201108/t20110805_3319944.html

http://www.big.cas.cn/xwzx/kyjz/201104/t20110418_3117523.html

http://www.big.cas.cn/xwzx/zhxw/201305/t20130506_3832944.html(PU Jiachen)

http://www.big.ac.cn/xwzx/zhxw/201205/t20120504_3572144.html(YANG Xuejing)

 

Telephone: +86-10-84097528

Email: wangqf (AT) big.ac.cn