Faculty

WANG Qianfei
E-mail:wangqf@big.ac.cn

Group leader  

 

Dr. WANG Qianfei "Jeffrey" is currently a professor and the Vice Director of CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics (BIG), Chinese Academy of Sciences (CAS). He is also a joint professor at the State Key Laboratory of Experimental Hematology and a member of the 13th and 14th expert committee in Medical Sciences of National Natural Science Foundation of China. He was awarded the National Science Fund for Distinguished Young Scholars in 2014.

 

Dr. WANG received his bachelor degree in clinical medicine from Shandong Medical University in China. He then earned his Ph.D. from Johns Hopkins University School of Medicine in 2002 (thesis advisors: Drs. Mark Schlissel and Alan Friedman). Under the supervision of Dr. Edward Rubin, Dr. WANG pursued his postdoctoral training in the Genomics Division at Lawrence Berkeley National Laboratory, University of California, Berkeley. Before Dr. WANG joined the faculty at Beijing Institute of Genomics, he was an Assistant Professor (Research Associate) at Section of Hematology/Oncology, the University of Chicago (2007-2009). Dr. WANG's background in clinical medicine, experimental biology and genomics has provided him with a unique opportunity to decipher the molecular mechanism and regulatory network controlling hematopoiesis and the development of human leukemia.

 

Introduction  

  

Leukemia is a malignant disease characterized by the uncontrolled accumulation of blood cells. Leukemia causes more deaths than any other cancer among children and young adults under the age of 20. Despite multi agent chemotherapy and stem cell transplantation, the overall survival rate of acute myeloid leukemia is less than 30%.

 

Through integrative programs combining biochemistry, cellular/molecular biology, and powerful genomics technology platforms, we seeks to transform original raw genomics data and basic research insights into knowledges of precision medicine related to AML diagnosis and treatment. Our lab has employed a combined genomic and functional characterization strategy to:

 

1) Integrative genomic and functional analysis of acute leukemic

 

2) Genomic and clinical study of clonal evolution in human leukemia

 

3) Megakaryocytes and platelets: Development and in vitro regeneration from stem cells

 

Selected Publications 

 

1. Zhang P , He FH, Bai J, Yamamoto S, Chen S, Zhang L, Sheng MY, Zhang L, Guo Y, Man N, Yang H, Wang SY, Cheng T, Nimer SD, Zhou Y, Xu MJ*, Wang QF* and Yang FC*. Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy. J Clin Invest. 2018 Oct 29. pii: 121366. doi: 10.1172/JCI121366. [Epub ahead of print]

 

2. Yang XJ, Lu B, Sun XQ, Han CJ, Fu CL, Xu KL, Wang M, Li DJ, Chen ZC, Opal P, Wen Q, Crispino JD, Wang QF*, Huang Z*. ANP32A regulates histone H3 acetylation and promotes leukemogenesis. Leukemia. 2018 Feb 2. doi: 10.1038/s41375-018-0010-7. [Epub ahead of print]

 

3. Bu JC, Chen AL, Yan XM, He FH, Dong YZ, Zhou YL, He JL, Zhan D, Lin PP, Hayashi Y, Sun YL, Zhang Y, Xiao ZJ, Grimes HL, Wang QF* and Huang G*. SETD2 mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia. Leukemia. 32(4):890-899,2018

 

4. Li YY, Jin C, Bai H, Gao YX, Sun S, Chen L, Qin L, Liu PP, Cheng LZ*, Wang QF*. Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation. Blood. 131(2):191-201,2018

 

5. Huang L, Liu D, Wang N, Ling SP, Tang YT, Wu J, Hao LT, Luo H, Hu XL, Sheng LS, Zhu LJ, Wang D, Luo Y, Shang Z, Xiao M, Mao X, Zhou KG, Cao LH, Dong LL, Zheng XC, Sui PP, He JL, Mo SL, Yan J, Ao QL, Qiu LG, Zhou HS, Liu QF, Zhang HY, Li JY, Jin J, Fu L, Zhao WL, Chen JP, Du X, Qing GL, Liu HD, Liu X, Huang G, Ma D, Zhou JF*, Wang QF*. Integrated Genomic Analysis Identifies Deregulated JAK/STAT-MYC-Biosynthesis Axis in Aggressive NK-cell Leukemia.Cell Research. 28(2):172-186,2018

 

6. Zhan D, Zhang YC, Xiao PF, Zheng XC, Ruan M, Zhang JL, Chen AL, Zou Y, Chen YM, Huang G, Hu SY, Wang QF*, Zhu XF*. Whole exome sequencing identifies novel mutations of epigenetic regulators in chemorefractory pediatric acute myeloid leukemia. Leukemia Research. 65:20-24, 2018

 

7. Zhang P, Xing CH, Rhodes SD, He YZ, Deng K, Li ZM, He FH, Zhu CY, Nguyen L, Zhou Y, Chen S, Mohammad K S, Guise TA, Abdel-Wahab O, Xu MJ, Wang QF* and Yang FC*. Loss of asxl1 alters self-renewal and cell fate of bone marrow stromal cell, leading to Bohring-Opitz-like syndrome in Mice. Stem Cell Reports. 6(6):914-925,2016

 

8. Li JP, He FH, Zhang P, Chen S, Shi H, Sun YL, Guo Y, Yang H, Man N, Greenblatt S, Li ZM, Guo ZY, Zhou Y, Wang L, Morey L, Williams S, Chen X, Wang QT, Nimer S, Yu P, Wang QF*, Xu MJ* and Yang FC*. Loss of Asxl2 leads to myeloid malignancies in mice. Nature Communications. 2017 Jun 8;8:15456. doi: 10.1038/ncomms15456

 

9. Chen AL, Yang JY, Hu SY* and Wang QF*. The priming inducton regimen of HAG as a low dose strategy in AML clonal evolution. Sci China Life Sci.58(12),1302-1305,2015

 

10. Zhu XF, He FH, Zeng HM, Ling SP, Chen AL, Wang YQ, Yan XM, Wei W, Pang YK, Cheng H, Hua CL, Zhang Y, Yang XJ, Lu X, Cao LH , Hao LT, Dong LL, Zou W, Wu J, Li X, Zheng S, Yan J, Zhou J, Zhang LX , Mi SL, Wang XJ, Zhang L, Zou Y, Chen YM, Geng Z, Zhou JF, Wang JM, Liu X, Wang JX, Yuan WP, Huang G*, Cheng T* and Wang QF*. Identification of functional cooperative mutations of SETD2 in human acute leukemia. Nature Genetics. 46(3): 287-293, 2014

 

11. Zhou J, Wu J, Li B, Liu D, Yu J, Yan XM, Zheng S, Wang JG, Zhang LX, Zhang L, He FH, Li Q, Chen AL, Zhang Y, Zhao XH, Guan YH, Zhao XH, Yan J, Ni J, Nobrega M, L?wenberg B, Delwel R, Valk P J, Kumar A, Xie L, Tenen DG, Huang G* and Wang QF*. PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway. Leukemia. 28(7): 1436-1448, 2014

 

12. Wang QF*, Li YJ, Dong JF, Li B, KaberleinJJ, Zhang L, Arimura FE, Luo RT, Ni J, He FH, Wu J, Mattison R, Zhou J, Wang CZ, Prabhakar S, Nobrega M A and Thirman M J*. Regulation of MEIS1 by distal enhancer elements in acute leukemia. Leukemia.28(1):138-146, 2014

 

13. Wang QF, Wu G, Mi SL, He FH, Wu J, Dong JF, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji HK and Thirman MJ. MLL fusion proteins preferentially regulate a subset of wild type MLL target genes in the leukemic genome. Blood.117(25):6895-6905, 2011

 

14. Wang QF*, Prabhakar S, Chanan S, Cheng JF, Rubin EM and Boffelli D*. Detection of weakly conserved ancestral mammalian regulatory sequences by primate comparisons. Genome Biology. 8(1):R1, 2007

 

15. Wang QF#, Prabhakar S#, Wang Q, Moses A, Chanan S, Brown M, Eisen M, Cheng JF, Rubin E and Boffelli D. Primate-specific evolution of an LDLR enhancer. Genome Biology.7(8):R68, 2006

 

16. Wang QF, Liu X, O’nell J, Peng Z, Krauss R, Rainwater DL, Vandeberg JL, Rubin EM, Cheng J F and Pennacchio LA. Haplotypes in the APOA1-C3-A4-A5 Gene Cluster affect Plasma Lipids in both Humans and Baboons. Human Molecular Genetics.13(10):1049-1056,2004

 

17. Wang QF, Cleaves R, Kummalue T, Nerlov C and Friedman A D. Cell cycle inhibition mediated by the outer surface of the C/EBPalpha basic region is required but not sufficient for granulopoiesis. Oncogene. 22(17):2548-2557,2003

 

18. Wang QF and Friedman A D. C/EBPs are required for granulopoiesis independent of their induction of the granulocyte-colony stimulating factor receptor. Blood. 99(8):2776-2785, 2002

 

19. Wang QF, Lauring J, and Schlissel M S. c-Myb binds to a sequence in the proximal region of the RAG-2 promoter and is essential for promoter activity in T-lineage cells.Molecular and Cellular Biology.20:9203-9211,2000

 

Patents  

 

Cheng Tao, Wang Qianfei, Zhu Xiaofan, Yuan Weiping, Assay kit for detecting mutations in the SETD2 gene (SETD2), 2015.3.11, China, ZL 201310107889.9

 

Awards and Honors 

 

2014 The National Science Fund for Distinguished Young Scholars

2015 Zhu Liyuehua Excellent Teacher Award

2015 National Hundred, Thousand and Ten Thousand Talents Project

2016 State Council Expert for Special Allowance

 

Group Members 

 

Staff: 

 

YAN Jin: Research assistant

LI Yueying: Research assistant professor (Experimental biology)

CHEN Aili: Research assistant professor (Experimental biology)

YU Xuexin: Research assistant professor (Bioinformatics)

 

Graduate Students

 

2011

YANG Xuejing

2013

JIN Chen

2015

YANG Jingyi

SUN Shu

2016

ZHANG Ya

CHEN Lei

ZHANG Chen

2017

HE Minkun

QIN Lei

JIANG Shuting

LEI Ying

GU Wen

2018

SI Jia

LIU Jingkun

HU Haiyang

ZHOU Zihan

 

Visiting Graduate Students:  

 

2017

ZHAO Jianxin

YAN Shen

 

Lab News Links: 

 

http://m.cyol.com/content/2017-06/27/content_16236916.htm 

http://news.sciencenet.cn/htmlnews/2017/6/380511.shtm?from=timeline&isappinstalled=0 

http://t.cn/RgthkPo 

http://dwz.cn/6DlK56 

http://dwz.cn/3ui4pR 

http://scitech.people.com.cn/n/2015/0605/c1007-27107129.html 

http://news.xinhuanet.com/tech/2015-02/04/c_1114251835.htm 

http://news.cntv.cn/2014/02/13/VIDE1392248522320199.shtml 

http://paper.people.com.cn/rmrbhwb/html/2014-02/11/content_1389066.htm 

http://www.big.cas.cn/xwzx/zhxw/201601/t20160129_4527272.html 

http://www.big.ac.cn/xwzx/kyjz/201412/t20141205_4269647.html 

http://www.big.cas.cn/xwzx/zhxw/201108/t20110805_3319944.html 

http://www.big.cas.cn/xwzx/kyjz/201104/t20110418_3117523.html 

Telephone: +86-10-84097528

Email: wangqf (AT) big.ac.cn